ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Phosphate, Tribasic → 5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide

HRID 1037537
ノート
印刷プレビュー

反応式

HRID 1037537 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([C:17]([NH:19][CH3:20])=[O:18])=[C:15]3[C:10]([CH:11]=[C:12]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])[C:13]([CH:21]4[CH2:23][CH2:22]4)=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1.B1(C(C)=C)O[C:32](C)(C)[C:31](C)([CH3:36])O1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].C1(P(C2CCCCC2)C2CCCCC2)CCCCC1>CC([O-])=O.CC([O-])=O.[Pd+2].O.C1(C)C=CC=CC=1>[CH:21]1([C:13]2[C:12]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])=[CH:11][C:10]3[C:15](=[C:16]([C:17]([NH:19][CH3:20])=[O:18])[N:8]([C:5]4[CH:6]=[CH:7][C:2]([C:31]([CH3:36])=[CH2:32])=[CH:3][CH:4]=4)[N:9]=3)[CH:14]=2)[CH2:23][CH2:22]1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 62657Potassium Phosphate, TribasicHCID 75806TricyclohexylphosphineHCID 109974264,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolaneHCID 56962687HCID 56962687、化合物

生成物 1

HCID 675126445-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide収率 36.2%

試薬・触媒・溶媒

3
HCID 167845palladium(II) acetate触媒HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
95 °C

実験手順

2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2H-indazole-3-carboxamide (i) (30 mg, 0.065 mmol), 2-isopropenylboronic acid pinacol ester (37 μL, 0.20 mmol), potassium phosphate (55 mg, 0.26 mmol), tricyclohexylphosphine (3.5 mg, 0.013 mmol) and Pd(OAc)2 (2.1 mg, 0.0094 mmol) had degassed toluene (1 mL) and water (0.1 mL) added and the reaction was heated at 95° C. under argon for 5 h. The reaction mixture was concentrated to dryness and the residue was suspended in DMSO (1 mL), centrifuged, supernatant removed and purified by reverse phase flash column chromatography eluting with ACN/water (0-40-100%) affording 5-cyclopropyl-N-methyl-6-[(methylsulfonyl)amino]-2-[4-(prop-1-en-2-yl)phenyl]-2H-indazole-3-carboxamide (ii) as a white solid (10 mg, 27%).

後処理

  1. additionadded
  2. concentrationThe reaction mixture was concentrated to dryness
  3. customcentrifuged, supernatant removed
  4. custompurified by reverse phase flash column chromatography
  5. washeluting with ACN/water (0-40-100%)

出典と根拠

ORDレコード
ord-fa5cd9f918a1472d90ef2971fd576fe1
出典データセット
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08546389B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート