Heptane → 2-[2-Amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-benzenesulfonamide

HRID 1037690ノート

反応式

HRID 1037690 の反応式
[NH2:1][C:2]1[N:11]=[C:10]([C:12]([N:14]2[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15]2)=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[S:29]([NH:32]C(C)(C)C)(=[O:31])=[O:30])[CH:8]=2)[N:3]=1.CCCCCCC>FC(F)(F)C(O)=O>[NH2:1][C:2]1[N:11]=[C:10]([C:12]([N:14]2[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15]2)=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[S:29]([NH2:32])(=[O:31])=[O:30])[CH:8]=2)[N:3]=1

参加物

4

反応物 2

HCID 8900HeptaneHCID 467017542-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-N-tert-butylbenzenesulfonamide

生成物 1

HCID 467017552-[2-Amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

反応条件

温度
22 °C

実験手順

1 g of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-N-tert-butylbenzenesulfonamide is dissolved in 10 ml of trifluoroacetic acid and stirred at 22° C. for 16 h. 10 ml of n-heptane are subsequently added and evaporated to dryness in vacuo. The crude product obtained in this way is purified by column chromatography.

後処理

  1. customevaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-7df3e7f04c984261b4c67c55e90d665b
出典データセット
uspto-grants-2013_10
特許番号
US08546565B2

反応ノート

読み込み中…