Sodium Hydroxide → 2-Chloro-6-iodo-4-(trifluoromethyl)aniline
反応式
[I:1]Cl.[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH2:14].[OH-].[Na+]>Cl.O>[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:12])([F:13])[F:11])[CH:7]=[C:6]([I:1])[C:5]=1[NH2:14]参加物
6
反応条件
- 温度
- 50 °C
実験手順
Iodine monochloride (17.2 g, 108 mmol) in hydrochloric acid (36%, 21.4 g) and water (35 mL) was added dropwise to 2-chloro-4-(trifluoromethyl)benzenamine (20.0 g, 102 mmol) in hydrochloric acid (36%, 20.7 g) and water (140 mL). The mixture was warmed to 50° C. for a total of 8 h. Sodium hydroxide (50%, 33.5 g, 419 mmol) was added to the mixture at room temperature. The mixture was extracted with dichloromethane (2×250 mL), and the extracts were dried and evaporated to give the product as an oil (31.83 g, 97% yield).
後処理
- extractionThe mixture was extracted with dichloromethane (2×250 mL)
- customthe extracts were dried
- customevaporated
出典と根拠
- ORDレコード
- ord-d3eda9272e92406abb9d60be17ad1a3e
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08546618B2
反応ノート
読み込み中…