Lithium Hydroxide → 3-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acid

HRID 1042470ノート

反応式

HRID 1042470 の反応式
C[O:2][C:3](=[O:19])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:7]=1[CH2:16][CH2:17][CH3:18].[Li+].[OH-]>C1COCC1.O>[CH2:16]([C:7]1[CH:8]=[C:9]([C:12]([F:13])([F:15])[F:14])[CH:10]=[CH:11][C:6]=1[CH:5]=[CH:4][C:3]([OH:19])=[O:2])[CH2:17][CH3:18]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 668554943-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acid methyl ester

生成物 1

HCID 668558853-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acid収率 74.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of 3-(2-propyl-4-trifluoromethyl-phenyl)-acrylic acid methyl ester (220 mg, 0.81 mmol) in THF (3 mL) was added a solution of 1N-LiOH (6 ml), and the mixture was stirred for 3 hours at room temperature. The reaction mixture was diluted with H2O, which was washed three times with EtOAc, acidified with 1N HCl to pH 1-2. The resulting solution was extracted three times with methylene chloride and then dried over anhydrous MgSO4 and concentrated in vacuo to give the title compound (155 mg, 74%).

後処理

  1. washwas washed three times with EtOAc
  2. extractionThe resulting solution was extracted three times with methylene chloride
  3. dry with materialdried over anhydrous MgSO4
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0412593cba6d4241acb54ea9dce995d6
出典データセット
uspto-grants-2013_10
特許番号
US08557872B2

反応ノート

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