Lithium Hydroxide → HCID 66857134、化合物

HRID 1042503ノート

反応式

HRID 1042503 の反応式
C([O:3][C:4](=[O:21])[C:5]([CH3:20])=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][C:8]=1[CH2:17][CH2:18][CH3:19])C.[Li+].[OH-]>C1COCC1.O>[CH3:20][C:5](=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:14])([F:15])[F:16])=[CH:9][C:8]=1[CH2:17][CH2:18][CH3:19])[C:4]([OH:21])=[O:3]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 66856173HCID 66856173、化合物

生成物 1

HCID 66857134HCID 66857134、化合物収率 96%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of 2-methyl-3-(2-propyl-4-trifluoromethyl-phenyl)-acrylic acid ethyl ester (68 mg, 0.23 mmol) in THF (1 mL) was added a solution of 1N-LiOH (10 ml), and the mixture was stirred for 3 hours at room temperature. The resulting residue was dissolved in H2O and then washed three times with EtOAc, acidified with 1N HCl to pH 1-2. The solution was extracted three times with methylene chloride and then dried over anhydrous MgSO4 and concentrated in vacuo to give the title compound (60 mg, 96%).

後処理

  1. washwashed three times with EtOAc
  2. extractionThe solution was extracted three times with methylene chloride
  3. dry with materialdried over anhydrous MgSO4
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-14c1c645b90048b38b2b77dd907ebbae
出典データセット
uspto-grants-2013_10
特許番号
US08557872B2

反応ノート

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