Trifluoroacetic acid → (3s,6r,7As)-6-amino-5-oxohexahydropyrrolizine-3-carbonitrile trifluoroacetate

HRID 10426

反応式

HRID 10426 の反応式
[C:1]([C@@H:3]1[CH2:10][CH2:9][C@@H:8]2[N:4]1[C:5](=[O:19])[C@H:6]([NH:11]C(=O)OC(C)(C)C)[CH2:7]2)#[N:2].C1(SC)C=CC=CC=1.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[NH2:11][C@@H:6]1[CH2:7][C@H:8]2[N:4]([C@H:3]([C:1]#[N:2])[CH2:10][CH2:9]2)[C:5]1=[O:19]

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 91321587Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate

生成物 1

HCID 11357934(3s,6r,7As)-6-amino-5-oxohexahydropyrrolizine-3-carbonitrile trifluoroacetate

実験手順

80 mg of tert-butyl ((2R,5S,7aS)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate were C reacted with 10% thioanisole in 1 ml of trifluoroacetic acid for 30 min. The solvents were then removed in vacuo, and the residue was stirred with diusopropyl ether.

後処理

  1. customThe solvents were then removed in vacuo

出典と根拠

ORDレコード
ord-300496268f1a4ca7a2622d242dab1799
出典データセット
uspto-grants-2006_08
特許番号
US07094800B2

関連ノート

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