Methyl iodide → 1-Bromo-4-(1-methoxy-2-methylpropan-2-yl)benzene

HRID 1043495ノート

反応式

HRID 1043495 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:12])([CH3:11])[CH2:9][OH:10])=[CH:4][CH:3]=1.I[CH3:14].[H-].[Na+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:12])([CH3:11])[CH2:9][O:10][CH3:14])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 128051244-Bromo-beta,beta-dimethylbenzeneethanol

生成物 1

HCID 102434781-Bromo-4-(1-methoxy-2-methylpropan-2-yl)benzene収率 87%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of the material from Step 2 (500 mg, 2.18 mmol) in 8 mL of DMF was added iodomethane (0.68 mL, 10.9 mmol) and NaH (60% in oil, 131 mg, 3.28 mmol). The mixture was stirred at room temperature for 2 h. The reaction was quenched with water, and extracted with EtOAc and hexane. The organic layer was separated, washed with saturated sodium bicarbonate, dried over MgSO4, and concentrated. The crude was purified by flash silica column (eluting with 5% EtOAc in hexane) to get 1-bromo-4-(1-methoxy-2-methylpropan-2-yl)benzene (460 mg, 87%).

後処理

  1. customThe reaction was quenched with water
  2. extractionextracted with EtOAc and hexane
  3. customThe organic layer was separated
  4. washwashed with saturated sodium bicarbonate
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated
  7. customThe crude was purified by flash silica column (eluting with 5% EtOAc in hexane)

出典と根拠

ORDレコード
ord-a69c2774eca340ad87fa687cc17552df
出典データセット
uspto-grants-2013_10
特許番号
US08563543B2

反応ノート

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