4-Chloroaniline → (4-Chloro-phenylamino)-phenyl-acetic acid

HRID 1044040

反応式

HRID 1044040 の反応式
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1>C(#N)C>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][CH:2]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:3]([OH:5])=[O:4])=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 78124-ChloroanilineHCID 97919Bromo(phenyl)acetic acid

生成物 1

HCID 305145(4-Chloro-phenylamino)-phenyl-acetic acid収率 47%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
100 °C

実験手順

To a solution of α-bromophenylacetic acid (1.00 g, 4.65 mmol) in acetonitrile (20 ml), was added 4-chloro-phenylamine (1.18 g, 9.30 mmol), and the mixture was heated under microwave irradiation at 100° C. for 1 hour (UPLC-MS monitoring: complete conversion). The solvent was evaporated, and the residue was positioned between EtOAc and 1N HCl. The organic phase was dried over Na2SO4, filtered and evaporated to dryness to obtain intermediate I11 (0.57 g; 47% yield).

後処理

  1. customThe solvent was evaporated
  2. dry with materialThe organic phase was dried over Na2SO4
  3. filtrationfiltered
  4. customevaporated to dryness
  5. customto obtain intermediate I11 (0.57 g; 47% yield)

出典と根拠

ORDレコード
ord-932593593b624f02a12186934c13286b
出典データセット
uspto-grants-2013_10
特許番号
US08563577B2

関連ノート

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