Nitrogen → 1-(2-Bromo-1,3-thiazol-5-yl)ethan-1-one

HRID 1044752

反応式

HRID 1044752 の反応式
N#N.[Br:3][C:4]1[S:5][C:6]([CH:9]([OH:11])[CH3:10])=[CH:7][N:8]=1>CC#N.O=[Mn]=O>[Br:3][C:4]1[S:5][C:6]([C:9](=[O:11])[CH3:10])=[CH:7][N:8]=1

参加物

5

反応物 2

HCID 947NitrogenHCID 591351941-(2-Bromothiazol-5-yl)ethanol

生成物 1

HCID 575628131-(2-Bromo-1,3-thiazol-5-yl)ethan-1-one

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6342Acetonitrile溶媒

実験手順

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(2-bromo-thiazol-5-yl)-ethanol (14.85 g, 71.37 mmol) in CH3CN (160 mL) was treated at rt with MnO2 (34.47 g, 356.84 mmol) and the reaction mixture was stirred for 20 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow solid. TLC:rf (1:1 hept-EA)=0.54. LC-MS-conditions 02: tR=0.79 min.

後処理

  1. filtrationbefore being filtered through Celite
  2. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-d6181ba5f0ef4e5a8c7052124afbce82
出典データセット
uspto-grants-2013_10
特許番号
US08563714B2

関連ノート

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