Nitrogen → 1-(4-Chloromethyl-thiazol-2-yl)ethanone

HRID 1044778

反応式

HRID 1044778 の反応式
N#N.[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([CH:10]([OH:12])[CH3:11])[S:8][CH:9]=1>CC#N.O=[Mn]=O>[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([C:10](=[O:12])[CH3:11])[S:8][CH:9]=1

参加物

5

反応物 2

HCID 947NitrogenHCID 668198411-(4-Chloromethyl-thiazol-2-yl)-ethanol

生成物 1

HCID 668199771-(4-Chloromethyl-thiazol-2-yl)ethanone

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6342Acetonitrile溶媒

実験手順

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(4-chloromethyl-thiazol-2-yl)-ethanol (2.19 g, 12.31 mmol) in CH3CN (122 mL) was treated at rt with MnO2 (5.94 g, 61.52 mmol). The reaction mixture was stirred at rt until completion of the reaction, and then filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.84 min.

後処理

  1. filtrationfiltered through Celite
  2. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-79154917368b43f5baddd6744e4b48ad
出典データセット
uspto-grants-2013_10
特許番号
US08563714B2

関連ノート

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