Azobisisobutyronitrile → 5-(Bromomethyl)-4-(4-chlorophenyl)-2-fluoropyridine
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([CH3:14])=[CH:12][N:11]=[C:10]([F:15])[CH:9]=2)=[CH:4][CH:3]=1.[Br:16]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[Br:16][CH2:14][C:13]1[C:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)=[CH:9][C:10]([F:15])=[N:11][CH:12]=1参加物
5
実験手順
A mixture of EXAMPLE 307A (1.2 g), N-bromosuccinimide (1.06 g) and AIBN (azobisisobutyronitrile) (0.178 g) in CCl4 (30 mL) was heated under reflux for 6 hours. After cooling, the solid was filtered off The filtrate was concentrated and loaded onto a silica gel column eluting with 3% ethyl acetate in hexanes to give the title compound.
後処理
- temperatureunder reflux for 6 hours
- temperatureAfter cooling
- filtrationthe solid was filtered off The filtrate
- concentrationwas concentrated
- washeluting with 3% ethyl acetate in hexanes
出典と根拠
- ORDレコード
- ord-9eddeddba7634b4aaf37db7add2c5432
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08563735B2
反応ノート
読み込み中…