Methyl iodide → Methyl 5-iodo-1-methyl-1H-pyrazole-3-carboxylate

HRID 1046090ノート

反応式

HRID 1046090 の反応式
[I:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH2:10]C)=[O:8])[NH:4][N:3]=1.[C:12]([O-])([O-])=O.[K+].[K+].[CH3:18][I:19]>CC#N>[I:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[N:4]([CH3:12])[N:3]=1.[I:19][C:18]1[N:3]([CH3:2])[N:4]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[CH:6]=1

参加物

6

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178469149HCID 178469149、化合物

生成物 2

HCID 46835547Methyl 5-iodo-1-methyl-1H-pyrazole-3-carboxylateHCID 58485356HCID 58485356、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of ethyl 3-iodo-1H-pyrazole-5-carboxylate (600 mg, 2.56 mmol) and K2CO3 (609 mg, 4.51 mmol) in dry CH3CN (10 mL) was added MeI (974 mg, 6.77 mmol). The mixture was stirred at room temperature overnight under N2. After TLC showed that starting material had disappeared, the solid was filtered. Solvent was removed and the residue was purified to give methyl 3-iodo-1-methyl-1H-pyrazole-5-carboxylate and methyl 5-iodo-1-methyl-1H-pyrazole-3-carboxylate.

後処理

  1. filtrationthe solid was filtered
  2. customSolvent was removed
  3. customthe residue was purified

出典と根拠

ORDレコード
ord-5c4af730fc4c4038948decb4ea30eda5
出典データセット
uspto-grants-2013_10
特許番号
US08569292B2

反応ノート

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