Lithium Hydroxide → 6-(6-(3-ethylureido)-4-(4-(1-methyl-1H-pyrazol-4-yl)thiazol-2-yl)pyridin-3-yl)-1-((1-methyl-1H-imidazol-4-yl)methyl)-4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylic acid

HRID 1047135ノート

反応式

HRID 1047135 の反応式
[Li+].[OH-].[CH2:3]([NH:5][C:6](=[O:48])[NH:7][C:8]1[N:13]=[CH:12][C:11]([C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][N:23]=2)[N:20]([CH2:24][C:25]2[N:26]=[CH:27][N:28]([CH3:30])[CH:29]=2)[CH:19]=[C:18]([C:31]([O:33]CC)=[O:32])[C:17]3=[O:36])=[C:10]([C:37]2[S:38][CH:39]=[C:40]([C:42]3[CH:43]=[N:44][N:45]([CH3:47])[CH:46]=3)[N:41]=2)[CH:9]=1)[CH3:4].C1COCC1>CO>[CH2:3]([NH:5][C:6](=[O:48])[NH:7][C:8]1[N:13]=[CH:12][C:11]([C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][N:23]=2)[N:20]([CH2:24][C:25]2[N:26]=[CH:27][N:28]([CH3:30])[CH:29]=2)[CH:19]=[C:18]([C:31]([OH:33])=[O:32])[C:17]3=[O:36])=[C:10]([C:37]2[S:38][CH:39]=[C:40]([C:42]3[CH:43]=[N:44][N:45]([CH3:47])[CH:46]=3)[N:41]=2)[CH:9]=1)[CH3:4]

参加物

5

反応物 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 68749575ethyl 6-(6-(3-ethylureido)-4-(4-(1-methyl-1H-pyrazol-4-yl)thiazol-2-yl)pyridin-3-yl)-1-((1-methyl-1H-imidazol-4-yl)methyl)-4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylate

生成物 1

HCID 687500606-(6-(3-ethylureido)-4-(4-(1-methyl-1H-pyrazol-4-yl)thiazol-2-yl)pyridin-3-yl)-1-((1-methyl-1H-imidazol-4-yl)methyl)-4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2N LiOH (1 mL) was added to a mixture of ethyl 6-(6-(3-ethylureido)-4-(4-(1-methyl-1H-pyrazol-4-yl)thiazol-2-yl)pyridin-3-yl)-1-((1-methyl-1H-imidazol-4-yl)methyl)-4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylate, 86.3 mg, 0.14 mmol) in MeOH (imp and THF (1 mL). The resulting solution was stirred at room temperature for two hours. The solvent was removed and the residue was diluted with water and acidified with 1N HCl. The precipitated product was collected by filtration and washed with water and dried (60 mg).

後処理

  1. customThe solvent was removed
  2. additionthe residue was diluted with water
  3. filtrationThe precipitated product was collected by filtration
  4. washwashed with water
  5. customdried (60 mg)

出典と根拠

ORDレコード
ord-678d3bc7dc1f49c39ca21146fd728831
出典データセット
uspto-grants-2013_10
特許番号
US08569484B2

反応ノート

読み込み中…