Ethylamine hydrochloride → 6-Bromo-4-ethyl-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

HRID 1047281ノート

反応式

HRID 1047281 の反応式
Br[CH2:2][C:3]([NH:5][C:6]1[C:11](Br)=[N:10][C:9]([Br:13])=[CH:8][N:7]=1)=[O:4].[CH:14]([N:17](C(C)C)CC)(C)[CH3:15].Cl.C(N)C>C(#N)C>[Br:13][C:9]1[N:10]=[C:11]2[N:17]([CH2:14][CH3:15])[CH2:2][C:3](=[O:4])[NH:5][C:6]2=[N:7][CH:8]=1

参加物

5

反応物 3

HCID 11198Ethylamine hydrochlorideHCID 81531DiisopropylethylamineHCID 582983072-bromo-N-(3,5-dibromopyrazin-2-yl)acetamide

生成物 1

HCID 866446546-Bromo-4-ethyl-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one収率 36%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
70 °C

実験手順

To a solution of 2-bromo-N-(3,5-dibromopyrazin-2-yl)acetamide (See Example 4.A) (1 equiv) and diisopropylethylamine (3 equiv) in acetonitrile was added ethanamine hydrochloride (1.05 equiv). The solution was allowed to heat to 70° C. for 30 min. The solution was condensed under reduced pressure and purified using column chromatography (0-75% ethyl acetate in hexanes) to afford the title compound in 36% yield. MS (ESI) m/z 257.5 [M]+, 259.4 [M+2]+.

後処理

  1. customcondensed under reduced pressure
  2. custompurified

出典と根拠

ORDレコード
ord-1de2b9be7bff4c63979b6d501a24524b
出典データセット
uspto-grants-2013_10
特許番号
US08569494B2

反応ノート

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