Dimethylformamide → 2-Methyl-3-(trifluoromethyl)benzoyl chloride

HRID 1048635ノート

反応式

HRID 1048635 の反応式
[F:1][C:2]([F:14])([F:13])[C:3]1[C:4]([CH3:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](O)=[O:7].C(Cl)(=O)C([Cl:18])=O.CN(C)C=O>O1CCCC1>[F:1][C:2]([F:14])([F:13])[C:3]1[C:4]([CH3:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([Cl:18])=[O:7]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27755842-Methyl-3-(trifluoromethyl)benzoic acid

生成物 1

HCID 27756022-Methyl-3-(trifluoromethyl)benzoyl chloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
25 °C

実験手順

A mixture of 3-trifluoromethyl-2-methylbenzoic acid 5.00 g, oxalyl dichloride 3.42 g, N,N-dimethylformamide about 50 mg and tetrahydrofuran 200 mL was stirred at 25° C. for one hour. The reaction mixtures were concentrated under reduced pressure to give 3-trifluoromethyl-2-methylbenzoic acid chloride.

後処理

  1. customThe reaction mixtures
  2. concentrationwere concentrated under reduced pressure

出典と根拠

ORDレコード
ord-76b70cdc255b4caba04d9fc9274317ae
出典データセット
uspto-grants-2016_07
特許番号
US09380782B2

反応ノート

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