Iodoethane → 6-(3-fluorophenyl)-N-ethylpyrido[3,2-d]pyrimidin-4-amine

反応式

[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH2:18])[C:16]=3[N:17]=2)[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].I[CH2:22][CH3:23]>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[CH:13][N:14]=[C:15]([NH:18][CH2:22][CH3:23])[C:16]=3[N:17]=2)[CH:5]=[CH:6][CH:7]=1

参加物

反応物 3

HCID 6340Iodoethane

HCID 24758Sodium hydride

HCID 867039146-(3-Fluorophenyl)pyrido[3,2-d]pyrimidin-4-amine

生成物 1

HCID 867039176-(3-fluorophenyl)-N-ethylpyrido[3,2-d]pyrimidin-4-amine

実験手順

Following the same reaction and purification procedure, the amine 1 (150 mg, 0.62 mmol) was treated with sodium hydride 60% dispersion in mineral oil (37 mg, 0.94 mmol) and iodoethane (0.05 mL, 0.62 mmol) to provide 6-(3-fluorophenyl)-N-ethylpyrido[3,2-d]pyrimidin-4-amine 29.