Methyl iodide → 6-Bromo-1,3-dimethyl-1H-indole
反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[H-].[Na+].[CH3:14]I>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[CH:7][N:8]2[CH3:14])=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of 6-bromo-3-methyl-1H-indole (200 mg, 0.95 mmol) in DMF (8 mL) was added NaH (114 mg, 2.85 mmol, m %/60%). The mixture was stirred at room temperature for 1 h before the addition of MeI (162 mg, 1.14 mmol). The system was stirred at room temperature for 4 h then the mixture was quenched with water and extracted with EtOAc. The organic layer was concentrated to give crude product which was used in next step without further purification. LCMS (m/z): 224.1 [M+H]+.
後処理
- customthe mixture was quenched with water
- extractionextracted with EtOAc
- concentrationThe organic layer was concentrated
- customto give crude product which
- customwas used in next step without further purification
出典と根拠
- ORDレコード
- ord-bd6104608632445aabcb26bc882c55c3
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09388173B2
反応ノート
読み込み中…