Methyl 2-(3-acetyl-5-(benzyloxy)-1H-indazol-1-yl)acetate → Methyl 2-(3-acetyl-5-hydroxy-1H-indazol-1-yl)acetate
反応式
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13]CC3C=CC=CC=3)[CH:11]=2)[N:6]([CH2:21][C:22]([O:24][CH3:25])=[O:23])[N:5]=1)(=[O:3])[CH3:2]>C1COCC1.[Pd]>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([OH:13])[CH:11]=2)[N:6]([CH2:21][C:22]([O:24][CH3:25])=[O:23])[N:5]=1)(=[O:3])[CH3:2]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To methyl 2-(3-acetyl-5-(benzyloxy)-1H-indazol-1-yl)acetate (3.70 g, 10.9 mmol) in THF (80 mL) was added Pd/C (10%, 400 mg). The reaction mixture was stirred at 50° C. overnight under a H2 atmosphere. Then was filtered over a pad of Celite and the residue washed with CH2Cl2. Solvents were removed under reduced pressure to give the title compound. MS (LC/MS): 248.9 [M+H]+, 271.0 [M+Na]+; tR (HPLC conditions e): 3.36 min.