Potassium Iodide → (R)-2-Phenyl-2-pyrrolidin-1-yl-ethanol

HRID 1054375

反応式

HRID 1054375 の反応式
[NH2:1][C@H:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][OH:4].C(=O)([O-])[O-].[Na+].[Na+].Br[CH2:18][CH2:19][CH2:20][CH2:21]Br.[I-].[K+]>CC(O)C>[C:5]1([C@@H:2]([N:1]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:3][OH:4])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 80561,4-DibromobutaneHCID 10340Sodium CarbonateHCID 2724025(R)-beta-aminophenethyl alcohol

生成物 1

HCID 11030628(R)-2-Phenyl-2-pyrrolidin-1-yl-ethanol

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

To a solution of (R)-2-amino-2-phenyl-ethanol (0.5 g, 3.64 mmol) in 2-propanol (40 mL) were added sodium carbonate (1 g, 9.48 mmol), 1,4-dibromobutane (0.57 mL, 4.74 mmol) and potassium iodide (catalytic) in succession, and the mixture was refluxed overnight. After filtration, the solvent was removed under reduced pressure and the crude was used without further purification (0.53 g, 76%). LCMS method: 2, RT: 2.27 min; MI: 191-193 [M+1].

後処理

  1. temperaturethe mixture was refluxed overnight
  2. filtrationAfter filtration
  3. customthe solvent was removed under reduced pressure
  4. customthe crude was used without further purification (0.53 g, 76%)

出典と根拠

ORDレコード
ord-36f84046dbc34129b9f9824aea9f2e4a
出典データセット
uspto-grants-2016_07
特許番号
US09394301B2

関連ノート

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