2-Methoxyethylamine → N-(2-methoxyethyl)-3-oxobutanamide

HRID 1055210ノート

反応式

HRID 1055210 の反応式
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[CH2:6]=[C:7]1[O:11][C:9](=[O:10])[CH2:8]1>O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:9](=[O:10])[CH2:8][C:7](=[O:11])[CH3:6]

参加物

4

反応物 2

HCID 80182-MethoxyethylamineHCID 12661Diketene

生成物 1

HCID 337172N-(2-methoxyethyl)-3-oxobutanamide収率 83.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

33 ml (0.38 mol) methoxyethylamine were added dropwise to a solution of 30 g of diketene (0.36 mol) in 300 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 47.15 g (0.30 mol, 83% yield) of a white solid.

後処理

  1. customThe reaction mixture was evaporated
  2. customthe residue purified by column chromatography

出典と根拠

ORDレコード
ord-ecd36131f5e24b2faf1a9b1fa34723e9
出典データセット
uspto-grants-2016_07
特許番号
US09394324B2

反応ノート

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