Nitric Acid → 5-Fluoro-6-nitro-2,3-dihydro-1,3-benzoxazol-2-one

HRID 1058211

反応式

HRID 1058211 の反応式
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:7]=[CH:8][C:9]2[O:13][C:12](=[O:14])[NH:11][C:10]=2[CH:15]=1>O>[F:5][C:6]1[C:7]([N+:1]([O-:4])=[O:2])=[CH:8][C:9]2[O:13][C:12](=[O:14])[NH:11][C:10]=2[CH:15]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 2872085-Fluoro-2(3H)-benzoxazolone

生成物 1

HCID 112178355-Fluoro-6-nitro-2,3-dihydro-1,3-benzoxazol-2-one収率 88%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

In a 500-ml flask, place 100 ml of concentrated nitric acid (70%) and warm to 45° C. Add 30.6 g (0.2 m) of 5-fluoro-benzoxazol-2-one (1a; X=F) and stir at 50° C. for 3 hrs. Add 240 ml of water slowly, and stir and cool to room temperature. Collect solid, wash with water, and dry in air to give 35.0 g (88%) of 5-fluoro-6-nitro-benzoxazol-2-one (2a; X=F) as pale yellow solids.

後処理

  1. customIn a 500-ml flask, place
  2. stirringstir
  3. temperaturecool to room temperature
  4. customCollect solid
  5. washwash with water
  6. customdry in air

出典と根拠

ORDレコード
ord-9a5f5f647d1f4215a437c2010fcf77b0
出典データセット
uspto-grants-2003_02
特許番号
US06515176B1

関連ノート

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