HCID 18629909、化合物 → HCID 18629911、化合物
反応式
[N+:1]([C:4]1[C:9]2[N:10]=[C:11]([CH2:13][C:14]#[N:15])[O:12][C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-])=O>[Pd].C1COCC1.C(O)(=O)C>[NH2:1][C:4]1[C:9]2[N:10]=[C:11]([CH2:13][C:14]#[N:15])[O:12][C:8]=2[CH:7]=[CH:6][CH:5]=1参加物
5
実験手順
The mixture of 4-nitro-2-benzoxazoleacetonitrile (27.22 g, 0.13 mole) and Palladium on carbon (3 g) in THF (320 ml) and acetic acid (5 ml) in a Parr bottle was hydrogenated at 50 psi for 15 h. It was filtered over a patch of celite (1.5 cm) covered with activated carbon (0.5 cm) and washed with isopropyl ether. The filtrate was evaporated and the residue was triturated with isopropyl ether and propyl acetate and filtered to give 4-amino-2-benzoxazoleacetonitrile (14.16 g, 61%).
後処理
- filtrationIt was filtered over a patch of celite (1.5 cm)
- washwashed with isopropyl ether
- customThe filtrate was evaporated
- customthe residue was triturated with isopropyl ether and propyl acetate
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-f9109207cca944d6ba22065406ded143
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06521397B1
反応ノート
読み込み中…