4-Bromoaniline → N-(3-cyanophenyl)-N'-(4-bromophenyl)urea

HRID 1059541ノート

反応式

HRID 1059541 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[Br:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=1.O1CCCC1>C(Cl)(Cl)Cl>[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:17][C:16]2[CH:18]=[CH:19][C:13]([Br:12])=[CH:14][CH:15]=2)=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]

参加物

5

反応物 3

HCID 78074-BromoanilineHCID 8028TetrahydrofuranHCID 27333153-Isocyanatobenzonitrile

生成物 1

HCID 18630693N-(3-cyanophenyl)-N'-(4-bromophenyl)urea収率 80.5%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 3-cyanophenyl isocyanate (3.76 g, 26.1 mmol) and 4-bromoaniline (4.5 g, 26.1 mmol) in 1:1 tetrahydrofuran:chloroform (100 mL). After 72 h at ambient temperature, product was isolated by filtration, the filtrate was washed with cold chloroform and air dried to give 6.6 g of N-(3-cyanophenyl)-N′-(4-bromophenyl)urea (21 mmol).

後処理

  1. customproduct was isolated by filtration
  2. washthe filtrate was washed with cold chloroform and air
  3. customdried

出典と根拠

ORDレコード
ord-8181b82618894f04998a9cbf8dcd1e4c
出典データセット
uspto-grants-2003_02
特許番号
US06521614B1

反応ノート

読み込み中…