HCID 22283318、化合物 → HCID 22283192、化合物
反応式
[Br:1][CH2:2][CH:3]([C:5]1[C:13]2[S:12][C:11]([NH:14][C:15](=[O:17])[OH:16])=[N:10][C:9]=2[C:8]([O:18][CH3:19])=[CH:7][CH:6]=1)[OH:4]>C(Cl)(Cl)Cl.O=[Mn]=O>[Br:1][CH2:2][C:3]([C:5]1[C:13]2[S:12][C:11]([NH:14][C:15](=[O:16])[OH:17])=[N:10][C:9]=2[C:8]([O:18][CH3:19])=[CH:7][CH:6]=1)=[O:4]参加物
4
実験手順
1.6 g of rac-[7-(2-bromo-1 -hydroxy-ethyl)-4-methoxy-benzothiazol-2-yl]-carbamic acid methyll ester (0.0044 Mol) were dissolved in CHCl3 (100 ml) and treated with 3.8 g of MnO2 (0.044 Mol) for 3 hrs. at 70° C. The hot reaction mixture was filtered and subsequently concentrated. The crude product was crystallized from Et2O to yield the title compound as a beige solid (73%); F.p.: 250-260° C. (dec.).
後処理
- customat 70° C
- filtrationThe hot reaction mixture was filtered
- concentrationsubsequently concentrated
- customThe crude product was crystallized from Et2O
出典と根拠
- ORDレコード
- ord-58989a228bd241b1b5af991a333b4292
- 出典データセット
- uspto-grants-2003_02
- 特許番号
- US06521754B2
反応ノート
読み込み中…