Hydrogen Bromide → 2-Bromo-3-fluorobenzonitrile

温度

0 °C

2-Amino-3-fluorobenzonitrile (9.8 g, 71.9 mmol) was dissolved in hot 1,4-dioxane (10 mL), 48% hydrobromic acid (100 mL) was added and the mixture cooled to 0° C. before dropwise addition of sodium nitrite (5.71 g, 82.7 mmol) in water (10 mL) over 1.5 h. The resulting mixture was stirred at 0° C. for 1.5 h then poured onto a cooled (0° C.) solution of copper(I) bromide (31.0 g, 216 mmol) in 48% hydrobromic acid (25 mL). The solution was stirred at 0° C. for 15 min then heated at 50° C. for 20 min. The mixture was cooled to ambient temperature, diluted with water (600 mL) and extracted with ethyl acetate (2×200 mL). The combined organics were washed with 10% aqueous ammonia solution (200 mL), water (200 mL) and brine (250 mL), dried over anhydrous magnesium sulfate, filtered and evaporated to give an orange oil. Purification by chromatography on silica gel eluting with isohexane on a gradient of ethyl acetate (2-4%) gave 2-bromo-3-fluorobenzonitrile (7.05 g, 49%) as a pale brown solid: δH (360 MHz, CDCl3) 7.62-7.68 (1H, m), 7.74-7.85 (1H, ddd, J 9, 9 and 1), 7.74-7.85 (1H, ddd, J 8, 1 and 1).

1. additionthen poured onto
2. stirringThe solution was stirred at 0° C. for 15 min
3. temperaturethen heated at 50° C. for 20 min
4. temperatureThe mixture was cooled to ambient temperature
5. extractionextracted with ethyl acetate (2×200 mL)
6. washThe combined organics were washed with 10% aqueous ammonia solution (200 mL), water (200 mL) and brine (250 mL)
7. dry with materialdried over anhydrous magnesium sulfate
8. filtrationfiltered
9. customevaporated
10. customto give an orange oil
11. customPurification by chromatography on silica gel eluting with isohexane on a gradient of ethyl acetate (2-4%)

ORDレコード

ord-a229175179d5481f8370f5c8ca28fae7

出典データセット

uspto-grants-2005_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06960598B2