Benzylamine → HCID 178418897、化合物

HRID 1062352

反応式

HRID 1062352 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)S(O[Si](C)(C)C)(=O)=O.[OH-].[Na+].[CH2:23]([S:25][C:26]#[N:27])[CH3:24]>>[CH2:1]([NH:8][C:26](=[NH:27])[S:25][CH2:23][CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 7504BenzylamineHCID 10968Ethyl thiocyanateHCID 14798Sodium HydroxideHCID 65367Trimethylsilyl triflate

生成物 1

HCID 178418897HCID 178418897、化合物収率 100%

実験手順

Benzylamine (13.8 mg) was dissolved in ethyl thiocyanate (50 μl). To this solution, trimethylsilyl trifluoromethanesulfonate (25.7 μl) was added dropwise at room temperature. After continued stirring for 1 day at room temperature, 2N aqueous sodium hydroxide was added to the solution, which was then extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the titled compound (25.4 mg, yield 100%).

後処理

  1. extractionwas then extracted with ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-e3f6adbd7aaf4d26b16b1f08228e3eb5
出典データセット
uspto-grants-2005_11
特許番号
US06960689B2

関連ノート

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