Water → Tamsulosin

HRID 1063516

反応式

HRID 1063516 の反応式
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C@@H:14]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:27][CH3:28])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH3:15].Cl.[OH-].[Na+].O>CO>[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C@@H:14]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:27][CH3:28])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH3:15]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 5362376Tamsulosin Hydrochloride

生成物 1

HCID 129211Tamsulosin

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The crystals obtained in step d) were suspended in methanol (1 100 ml), the mixture was heated to reflux and sodium hydroxide solution (2M, 440 ml) was gradually added followed by water (350 ml). The mixture was cooled down to 10–15° C. Formed crystals were filtered and washed on filter with methanol (150 ml) and water (150 ml) mixture. Crystals were dried at 50° C. to give 340 g of product.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux
  3. temperatureThe mixture was cooled down to 10–15° C
  4. customFormed crystals
  5. filtrationwere filtered
  6. washwashed
  7. filtrationon filter with methanol (150 ml) and water (150 ml) mixture
  8. customCrystals were dried at 50° C.

出典と根拠

ORDレコード
ord-ea18e88a065b45fbb2f15def55bbb14e
出典データセット
uspto-grants-2005_11
特許番号
US06965051B2

関連ノート

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