Sodium Hydroxide → 2-[4-(2-aminoethyl)piperazin-1-yl]ethanol

HRID 1064818ノート

反応式

HRID 1064818 の反応式
[C:1]([CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][OH:12])[CH2:6][CH2:5]1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>C1COCC1.C(O)C>[NH2:2][CH2:1][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][OH:12])[CH2:6][CH2:5]1

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 22272590HCID 22272590、化合物

生成物 1

HCID 47424572-[4-(2-aminoethyl)piperazin-1-yl]ethanol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 4-(cyanomethyl)piperazine-1-ethanol (1.69 g, 10 mmol) in THF (20 ml) was added to a solution of lithium aluminum hydride in THF (20 ml, 20 mmol) in an argon stream with ice cooling, the mixture was stirred at room temperature for 5 minutes and heated to reflux for 90 minutes. The reaction solution was allowed to cool, diluted with ethanol with ice cooling and stirred at room temperature for 15 minutes after adding an aqueous 1N sodium hydroxide solution thereto. This was filtered off through celite and the filtrate was concentrated in vacuo to provide 4-(aminoethyl)piperazine-1-ethanol.

後処理

  1. temperatureheated
  2. temperatureto reflux for 90 minutes
  3. temperatureto cool
  4. stirringstirred at room temperature for 15 minutes
  5. filtrationThis was filtered off through celite
  6. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-539c88751648429f939d960524738f57
出典データセット
uspto-grants-2005_11
特許番号
US06969711B2

反応ノート

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