Acetic Acid → 4-Methylsulfonylacetophenone

HRID 1065

反応式

HRID 1065 の反応式
[O-][Mn](=O)(=O)=O.[K+].[CH3:7][C:8]([C:10]1[CH:15]=[CH:14][C:13](SC)=[CH:12][CH:11]=1)=[O:9].[S:18]([O-:21])([O-])=[O:19].[Na+].[Na+].[C:24](O)(=O)C>O>[CH3:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([S:18]([CH3:24])(=[O:21])=[O:19])=[CH:12][CH:11]=1)=[O:9]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 24437Sodium SulfiteHCID 745011-(4-(Methylthio)phenyl)ethan-1-oneHCID 516875Potassium Permanganate

生成物 1

HCID 825294-Methylsulfonylacetophenone

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A solution of 152 g (0.96 mol) of KMnO4 in 3.5 1 of water is introduced into a mixture of 117.1 g (0.7 mol) of 4-(methylthio)acetophenone, prepared in Example 2c, and 292 ml of acetic acid. 2.3 l of water are added and the reaction temperature is allowed to return to room temperature. Saturated sodium sulfite solution is added dropwise until the solution is decolorized. This is left to stand overnight at room temperature. The solid obtained is filtered off, washed copiously with water and recrystallized from 95% ethanol to give 91.5 g of 4-(methylsulfonyl)acetophenone.

後処理

  1. customto return to room temperature
  2. waitThis is left
  3. customThe solid obtained
  4. filtrationis filtered off
  5. washwashed copiously with water
  6. customrecrystallized from 95% ethanol

出典と根拠

ORDレコード
ord-6d44d87ee23a4984ad13cff1877a23a4
出典データセット
uspto-grants-1998_03
特許番号
US05723485

関連ノート

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