Lithium Hydroxide → HCID 54353537、化合物
反応式
Cl[C:2]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:3]=1[O:4][CH2:5][C:6]1[N:7]([CH3:22])[C:8]2[C:13]([C:14]=1[CH:15](O)[CH2:16][C:17]([O:19]C)=[O:18])=[CH:12][CH:11]=[CH:10][CH:9]=2.[OH-].[Li+]>O1CCCC1>[Cl:27][C:25]1[CH:24]=[CH:23][C:3]([O:4][CH2:5][C:6]2[N:7]([CH3:22])[C:8]3[C:13]([C:14]=2[CH:15]=[CH:16][C:17]([OH:19])=[O:18])=[CH:12][CH:11]=[CH:10][CH:9]=3)=[CH:2][CH:26]=1参加物
4
実験手順
Under a nitrogen atmosphere a round bottom flask is charged with 2-[(2,4-dichlorophenoxy)methyl]-1-methyl-3-[1-hydroxy-2-(methoxycarbonyl)ethyl]-1H-indole (Example 55) (0.149 g, 0.398 mmol) and 6.11 ml of dry tetrahydrofuran. To this solution is added 1.22 ml of a 2.0 N lithium hydroxide aqueous solution and the resulting mixture was stirred at room temperature for about two hours. The solvents were removed in vacuo and the residue is partitioned between methylene chloride and water. The aqueous fraction was extracted twice with methylene chloride. The organic fractions were combined and dried over sodium sulfate. The solvents were removed in vacuo. The desired title product was triturated with diethyl ether.