Chloroform → 4-Methoxyphenyl-3-O-allyl-2,4,6-tri-O-benzyl-b-D-galactopyranoside

HRID 1067046ノート

反応式

HRID 1067046 の反応式
[CH2:1]([O:4][C@H:5]1[C@@H:19]([OH:20])[C@@H:18]([CH2:21][OH:22])[O:17][C@@H:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[C@@H:6]1[OH:23])[CH:2]=[CH2:3].[H-].[Na+].[CH2:26](Br)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.C(Cl)(Cl)Cl>CN(C=O)C>[CH2:1]([O:4][C@H:5]1[C@@H:19]([O:20][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C@@H:18]([CH2:21][O:22][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[O:17][C@@H:7]([O:8][C:9]2[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][CH:14]=2)[C@@H:6]1[O:23][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH:2]=[CH2:3]

参加物

6

反応物 4

HCID 6212ChloroformHCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 155408674-Methoxyphenyl 3-O-prop-2-en-1-yl-beta-D-galactopyranoside

生成物 1

HCID 105794064-Methoxyphenyl-3-O-allyl-2,4,6-tri-O-benzyl-b-D-galactopyranoside収率 91%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
0 °C

実験手順

To a solution of compound 8 (1.21 g, 3.71 mmol) in anhydrous DMF (15 mL), under nitrogen and cooled at 0° C., was added NaH (116 mg, 4.83 mmol). The reaction mixture was stirred 15 minutes at 0° C. and treated with benzyl bromide (0.66 mL, 5.57 mmol). After 12 hours at room temperature, the reaction mixture was cooled at 0° C., quenched by slow addition of water and extracted with chloroform. The combined organic layers were washed with H2O, dried over anhydrous Na2SO4, filtered and the solvents were evaporated. Purification by chromatography on silica gel (ethyl acetate-petroleum ether, v/v 1:3) afforded 91% as white crystals in 91% yield (2.01 g). mp=59-61° C.; [αD]24=−23° (c 1, CHCl3); 1H NMR (500 MHz, CDCl3): δ3.48 (dd, 1H, J2,3 9.6 Hz, J3,4 2.8 Hz, H-3), 3.63 (bs, 3H, H-5, H-6a and H-6b), 3.75 (s, 3H, OMe), 3.90 (d, 1H, J4,5<1.5 Hz, H-4), 4.01 (dd, 1H, J1,2 7.8 Hz, H-2), 4.22 (m, 2H, OCH2), 4.40, 4.45, 4.64, 4.84, 4.96 and 4.97 (6 d, 1H each, JA,B 11.7 Hz, CH2Ph), 4.83 (d, 1H, H-1), 5.19 and 5.33 (2 dd, 1H each, CH═CH2), 5.95 (m, 1H, CH═CH2), 6.78 and 7.02 (2 d, 2H each, C6H4), 7.22-7.40 (m, 15H, 3C6H5). Anal. Calcd for C37H40O7 (596.7): C 74.48, H 6.76; found: C 74.32, H 6.75.

後処理

  1. waitAfter 12 hours at room temperature
  2. temperaturethe reaction mixture was cooled at 0° C.
  3. customquenched by slow addition of water
  4. extractionextracted with chloroform
  5. washThe combined organic layers were washed with H2O
  6. dry with materialdried over anhydrous Na2SO4
  7. filtrationfiltered
  8. customthe solvents were evaporated
  9. customPurification by chromatography on silica gel (ethyl acetate-petroleum ether, v/v 1:3)
  10. customafforded 91% as white crystals in 91% yield (2.01 g)

出典と根拠

ORDレコード
ord-5fd7f82a840344f3b2c806e0fc74d5c9
出典データセット
uspto-grants-2001_06
特許番号
US06245902B1

反応ノート

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