HCID 21196524、化合物 → HCID 18367302、化合物
反応式
O[CH:2]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[O:16][CH3:17])[CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=[O:9]>CO.CCOC(C)=O.[Pd].[OH-].[OH-].[Pd+2]>[CH3:17][O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=[O:9]参加物
5
実験手順
A mixture of 2-[hydroxy-(2-methoxyphenyl)methyl]-cyclohexanone (3.71 g), 10% Pd/C (wet) (1.0 g), and 20% Pd(OH)2/C (180 mg) in MeOH-EtOAc (2:1, 150 ml) was stirred under hydrogen atmosphere at room temperature for 28 hours. The catalyst was removed by filtration and the filtrate was evaporated. The residue was purified by silica gel column chromatography (hexane-EtOAc 7:1) to give 2-(2-methoxybenzyl)cyclohexanone (2.65 g) as an oil.
後処理
- customThe catalyst was removed by filtration
- customthe filtrate was evaporated
- customThe residue was purified by silica gel column chromatography (hexane-EtOAc 7:1)
出典と根拠
- ORDレコード
- ord-4b64e939b055410a93f6428e070f4e9b
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06245790B1
反応ノート
読み込み中…