Sodium Hydroxide → HCID 11746720、化合物
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:17])([CH3:16])[C:12]([O:14]C)=[O:13])[N:10]=2)[N:7]=1.[OH-].[Na+]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:17])([CH3:16])[C:12]([OH:14])=[O:13])[N:10]=2)[N:7]=1参加物
4
実験手順
1.40 g of methyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate was dissolved in 15 ml of tetrahydrofuran; 9 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by stirring at room temperature for 3 hours. After the mixture was concentrated under reduced pressure, the residue was ajusted to pH 4 by the addition of 1 N hydrochloric acid; the crystal precipitated was collected by filtration to yield 1.06 g of the title compound.
後処理
- concentrationAfter the mixture was concentrated under reduced pressure
- additionthe residue was ajusted to pH 4 by the addition of 1 N hydrochloric acid
- customthe crystal precipitated
- filtrationwas collected by filtration
出典と根拠
- ORDレコード
- ord-fbc17d51c48a4ace86d85166b36975db
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06248740B1
反応ノート
読み込み中…