Ethyl 6-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate → Ethyl 6-hydroxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate

HRID 1067820ノート

反応式

HRID 1067820 の反応式
C([O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[C:14]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:15]2[CH3:18])=[C:11]([C:24]([F:27])([F:26])[F:25])[CH:10]=1)C1C=CC=CC=1>[Pd].O1CCCC1>[OH:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[C:14]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[N:15]2[CH3:18])=[C:11]([C:24]([F:27])([F:25])[F:26])[CH:10]=1

参加物

4

反応物 1

HCID 21194669Ethyl 6-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate

生成物 1

HCID 22720038Ethyl 6-hydroxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

The reaction was carried out in a manner similar to Reference Example 15 a) except for using 2.23 g (5.91 mmol) of ethyl 6-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate, 0.3 g of 10% palladium/carbon and 50 ml of tetrahydrofuran. Ethyl 6-hydroxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate was thus obtained in an amount of 1.70 g.

出典と根拠

ORDレコード
ord-e1b4a6aa4a164e5c8208cdb499603088
出典データセット
uspto-grants-2001_06
特許番号
US06248772B1

反応ノート

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