Hydrochloric Acid → HCID 21193379、化合物

HRID 1068410ノート

反応式

HRID 1068410 の反応式
C[O:2][C:3](=[O:38])[CH:4]([C:14]1[N:15]=[CH:16][N:17]([C:19]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:18]=1)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=1.[OH-].[Li+].Cl>C1COCC1>[C:32]1([C:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:17]2[CH:18]=[C:14]([CH:4]([CH2:5][C:6]3[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=3)[C:3]([OH:38])=[O:2])[N:15]=[CH:16]2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 54160280HCID 54160280、化合物

生成物 1

HCID 21193379HCID 21193379、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of the 2-{1-(triphenylmethyl)-1H-imidazol-4-yl}-2-(4-cyanobenzyl)-acetic acid methyl ester in THF was treated with 1 equivalent of 1M lithium hydroxide solution. Upon consumption of starting material as determined by t.l.c, 1 equivalent of hydrochloric acid was added and the solution evaporated to dryness in vacuo. The material obtained in this manner could be used without further purification.

後処理

  1. customUpon consumption of starting material
  2. additionwas added
  3. customthe solution evaporated to dryness in vacuo
  4. customThe material obtained in this manner
  5. customcould be used without further purification

出典と根拠

ORDレコード
ord-5f4c566ec9f74772ae799378adb97b13
出典データセット
uspto-grants-2001_06
特許番号
US06248756B1

反応ノート

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