Sodium Hydroxide → (z)-5-[2,3-Dihydro-3-[(3-methoxy-1h-pyrrol-2-yl)methylene]-2-oxo-1h-indol-4-yl]-4-pentynoic acid sodium salt

HRID 1069671ノート

反応式

HRID 1069671 の反応式
[CH3:1][O:2][C:3]1[CH:7]=[CH:6][NH:5][C:4]=1/[CH:8]=[C:9]1\[C:10](=[O:25])[NH:11][C:12]2[C:17]\1=[C:16]([C:18]#[C:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23])[CH:15]=[CH:14][CH:13]=2.[OH-].[Na+:27]>O1CCCC1>[Na+:27].[CH3:1][O:2][C:3]1[CH:7]=[CH:6][NH:5][C:4]=1/[CH:8]=[C:9]1\[C:10](=[O:25])[NH:11][C:12]2[C:17]\1=[C:16]([C:18]#[C:19][CH2:20][CH2:21][C:22]([O-:24])=[O:23])[CH:15]=[CH:14][CH:13]=2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 9797846(Z)-5-[2,3-Dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-1H-indol-4-yl]-4-pentynoic acid

生成物 1

HCID 23683387(z)-5-[2,3-Dihydro-3-[(3-methoxy-1h-pyrrol-2-yl)methylene]-2-oxo-1h-indol-4-yl]-4-pentynoic acid sodium salt

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(Z)-5-[2,3-Dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-1H-indol-4-yl]-4-pentynoic acid (100 mg, 3 mmol) (from Example 10 above) was dissolved in tetrahydrofuran (1 mL), and 1N sodium hydroxide (3 mL) was added. The resulting product, (Z)-5-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-1H-indol-4-yl]-4-pentynoic acid sodium salt, was purified via reverse-phase HPLC (acetonitrile—water over 15 minutes).

後処理

  1. customThe resulting product, (Z)-5-[2,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-1H-indol-4-yl]-4-pentynoic acid sodium salt, was purified via reverse-phase HPLC (acetonitrile—water over 15 minutes)

出典と根拠

ORDレコード
ord-6e51d0a6e70441fd9eae328f627e5354
出典データセット
uspto-grants-2001_06
特許番号
US06252086B1

反応ノート

読み込み中…