Acetic Acid → 5-Methanesulfonyl-1H-indole-2-carboxylic acid

HRID 1070937

反応式

HRID 1070937 の反応式
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=2)=[O:4].[Li+].[OH-].C(O)(=O)C>C1COCC1.O>[CH3:17][S:14]([C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[NH:6][C:5]([C:3]([OH:4])=[O:2])=[CH:13]2)(=[O:16])=[O:15]

参加物

6

反応物 3

HCID 176Acetic AcidHCID 3939Lithium HydroxideHCID 735868Methyl 5-(methylsulfonyl)-1H-indole-2-carboxylate

生成物 1

HCID 223944465-Methanesulfonyl-1H-indole-2-carboxylic acid収率 23.8%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the 5-methanesulfonyl-1H-indole-2-carboxylic acid methyl ester (0.49 g) in THF (12 mL) and water (4 ml) was added LiOH (0.098 g). The reaction mixture was left to stir for 2 hours. Acetic acid was added and the product extracted with dichloromethane. The organic extracts were combined, dried with magnesium sulfate, filtered and the filtrate evaporated to give the title compound as a solid (0.110 g).

後処理

  1. waitThe reaction mixture was left
  2. extractionthe product extracted with dichloromethane
  3. dry with materialdried with magnesium sulfate
  4. filtrationfiltered
  5. customthe filtrate evaporated

出典と根拠

ORDレコード
ord-19a43f70378a4859a33c16891ead456e
出典データセット
uspto-grants-2005_06
特許番号
US06903115B2

関連ノート

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