Water → 4-Cyano-5-methyl-4-(3-thienyl)hexanol

HRID 1071636ノート

反応式

HRID 1071636 の反応式
O1CCCC1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].O.[C:15]([C:17]([C:28]1[CH:32]=[CH:31][S:30][CH:29]=1)([CH:25]([CH3:27])[CH3:26])[CH2:18][CH2:19][C:20](OCC)=[O:21])#[N:16]>>[C:15]([C:17]([C:28]1[CH:32]=[CH:31][S:30][CH:29]=1)([CH:25]([CH3:27])[CH3:26])[CH2:18][CH2:19][CH2:20][OH:21])#[N:16]

参加物

6

反応物 5

HCID 962WaterHCID 8028Tetrahydrofuran2 回HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 22393748Ethyl 4-cyano-5-methyl-4-(3-thienyl)hexanoate

生成物 1

HCID 223937214-Cyano-5-methyl-4-(3-thienyl)hexanol収率 95%

実験手順

A tetrahydrofuran solution (35 ml) in which ethyl 4-cyano-5-methyl-4-(3-thienyl)hexanoate (6.66 g) was dissolved was added dropwise to a tetrahydrofuran solution (50 ml) of lithium aluminum hydride (686 mg). After stirring for 2 hours, 2N aqueous NaOH and water were added to treat the mixture, and the resulting precipitates were filtered. The resulting filtrate was evaporated, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane system), to give the title compound as a yellow oil (5.30 g, 95%).

後処理

  1. additionto treat the mixture
  2. customthe resulting precipitates
  3. filtrationwere filtered
  4. customThe resulting filtrate was evaporated
  5. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane system)

出典と根拠

ORDレコード
ord-329c02ab1fd942cdb911f787f77129d2
出典データセット
uspto-grants-2005_06
特許番号
US06906072B1

反応ノート

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