Sodium Hydroxide → Carboxystyrylpyridine
反応式
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][C:5]=1[CH:10]=[CH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[OH-].[Na+]>C1COCC1>[CH:10]([C:5]1[N:6]=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:18])=[O:2])=[CH:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1参加物
4
実験手順
A solution of the ester 19 (55.0 g, 0.23 mol) in THF (100 mL) was treated with a 3 N NaOH solution (110 mL, 0.25 mol) for 21 h at ambient temperature. After removal of solvents, the residue was taken up in water and ethyl ether. The phases were separated, and the aqueous phase was washed with ether (2×). The resulting aqueous phase was neutralized with a 2 N HCl solution, and the precipitate was then collected by filtration to afford the acid 20 (50.2 g, 97%) as a cream solid:
後処理
- customAfter removal of solvents
- customThe phases were separated
- washthe aqueous phase was washed with ether (2×)
- filtrationthe precipitate was then collected by filtration
出典と根拠
- ORDレコード
- ord-e32b4f85d24441439429be6ad1edac27
- 出典データセット
- uspto-grants-2005_06
- 特許番号
- US06911460B2
反応ノート
読み込み中…