Oxalyl chloride → Carbonyl benzimidazole

HRID 1072539ノート

反応式

HRID 1072539 の反応式
[C:1](Cl)(=[O:5])[C:2](Cl)=O.COC1CCC(C(O)=O)CC1.NC1C=CC(C2[NH:26][C:27]3[CH:33]=[CH:32][C:31](N)=[CH:30][C:28]=3[N:29]=2)=CC=1>C(Cl)Cl.CN(C=O)C.N1C=CC=CC=1>[C:1](=[C:2]1[N:29]=[C:28]2[CH:30]=[CH:31][CH:32]=[CH:33][C:27]2=[N:26]1)=[O:5]

参加物

7

反応物 3

HCID 65578Oxalyl chlorideHCID 736153Rac-(1r,4r)-4-methoxycyclohexane-1-carboxylic acidHCID 178507432HCID 178507432、化合物

生成物 1

HCID 22387228Carbonyl benzimidazole

試薬・触媒・溶媒 3

HCID 6228Dimethylformamide触媒HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
60 °C

実験手順

Bis-4-methoxyclohexyl carbonyl benzimidazole was synthesized as follows: Oxalyl chloride, (1.07. ml, 2 M in CH2Cl2) was added to 4-methoxy-cyclohexane carboxylic acid (0.338 g, 2.14 mmole) followed by one drop DMF. The mixture was allowed to react at RT for 1.0 hour. To the above solution was added 2-(4-aminophenyl)-6-amino-benzimidazole (0.200 g, 0.89 mmole) in pyridine (2 ml). The reaction was heated to 60° C. overnight. The reaction was cooled and the precipitate filtered and washed with NaHCO3 and hexanes.

後処理

  1. customto react at RT for 1.0 hour
  2. temperatureThe reaction was cooled
  3. filtrationthe precipitate filtered
  4. washwashed with NaHCO3 and hexanes

出典と根拠

ORDレコード
ord-cfd0421849c2497a88f7d19f0c404465
出典データセット
uspto-grants-2005_06
特許番号
US06911462B2

反応ノート

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