Toluene → 5-Bromo-2-ethylbenzofuran
反応式
[C:1]([C:4]1[O:8][C:7]2[CH:9]=[CH:10][C:11]([Br:13])=[CH:12][C:6]=2[CH:5]=1)(=O)[CH3:2].O.NN.[OH-].[K+].C1(C)C=CC=CC=1>C(O)CO.O>[Br:13][C:11]1[CH:10]=[CH:9][C:7]2[O:8][C:4]([CH2:1][CH3:2])=[CH:5][C:6]=2[CH:12]=1参加物
7
反応条件
- 温度
- 150 °C
実験手順
2-Acetyl-5-bromobenzo[b]furan (10.00 g) and hydrazine monohydrate (8.00 g) were stirred in ethylene glycol (60 ml) at 150° C. for 2 hr. After cooling, potassium hydroxide (9.00 g) was added and the mixture was stirred at 150° C. for 2 hr. After cooling, toluene (200 ml) and water (100 ml) were added and the separated toluene layer was washed with 10% aqueous solution (100 ml) of ammonium chloride, dried over magnesium sulfate and concentrated to give the objective compound (8.30 g).
後処理
- temperatureAfter cooling
- temperatureAfter cooling
- washthe separated toluene layer was washed with 10% aqueous solution (100 ml) of ammonium chloride
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-77d1067699104ae3a41fd170add251e4
- 出典データセット
- uspto-grants-2005_06
- 特許番号
- US06911469B2
反応ノート
読み込み中…