Water → HCID 22388089、化合物

HRID 1072896ノート

反応式

HRID 1072896 の反応式
N1C=CC=CC=1.S(Cl)([Cl:9])=O.[Cl:11][C:12]1[CH:19]=[C:18]([O:20][CH:21]([CH3:23])[CH3:22])[CH:17]=[CH:16][C:13]=1[CH2:14]O.O>ClCCl>[Cl:11][C:12]1[CH:19]=[C:18]([O:20][CH:21]([CH3:23])[CH3:22])[CH:17]=[CH:16][C:13]=1[CH2:14][Cl:9]

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 24386Thionyl ChlorideHCID 22388433[2-Chloro-4-(propan-2-yloxy)phenyl]methanol

生成物 1

HCID 22388089HCID 22388089、化合物収率 106,483.797%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Pyridine (0.5 ml) and thionyl chloride (0.18 mg) were successively added to a solution of 2-chloro-4-isopropoxybenzylalcohol (401 mg) in dichloromethane (2 ml) under ice-cooling, and the mixture was stirred for 1 hr. Water was added to the reaction mixture and the resulting product was extracted three times with hexane. The organic layers were combined, washed successively with 1N hydrochloric acid, a saturated aqueous solution of sodium hydrogencarbonate and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the objective compound (353 mg) as a yellow oil.

後処理

  1. temperaturecooling
  2. extractionthe resulting product was extracted three times with hexane
  3. washwashed successively with 1N hydrochloric acid
  4. dry with materiala saturated aqueous solution of sodium hydrogencarbonate and saturated brine, and dried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-39e97d12777f450aa93e0d95a2de8aa2
出典データセット
uspto-grants-2005_06
特許番号
US06911469B2

反応ノート

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