Methyl iodide → HCID 15086005、化合物

HRID 1073221ノート

反応式

HRID 1073221 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1[CH2:10][OH:11])[C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[S:5]2.[H-].[Na+].[CH3:18]I>CN(C)C=O>[CH3:18][O:11][CH2:10][C:9]1[N:8]2[C:4]([S:5][C:6]3[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=32)=[N:3][C:2]=1[CH3:1]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 130922Nik 228

生成物 1

HCID 15086005HCID 15086005、化合物収率 60.8%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In 30 ml of dry dimethylformamide was suspended 2.18 g of 2-methylimidazo[2,1-b]benzothiazole-3-methanol and, 0.50 g of 60% sodium hydride was added to the suspension followed by stirring at room temperature for minutes. After 1.74 g of methyl iodide was added thereto, the mixture was stirred for one hour. Then ice water was added to the reaction mixture followed by extracting with ethyl acetate. After the ethyl acetate was removed, 1.41 g of the title compound was obtained.

後処理

  1. additionwas added to the suspension
  2. stirringthe mixture was stirred for one hour
  3. extractionby extracting with ethyl acetate
  4. customAfter the ethyl acetate was removed

出典と根拠

ORDレコード
ord-01542132dd454ae284a8761c91dbed3c
出典データセット
uspto-grants-1990_11
特許番号
US04968708

反応ノート

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