Methyl Isocyanate → (R,S)-Bis-(1-methyl-2,5-dioxo-4-imidazolidinyl-methyl)-disulphide

HRID 1073235

反応式

HRID 1073235 の反応式
[CH2:1]([S:7][S:8][CH2:9][C@H:10]([NH2:14])[C:11]([OH:13])=O)[C@H:2]([NH2:6])[C:3]([OH:5])=O.[CH3:15][N:16]=[C:17]=[O:18]>[OH-].[Na+]>[CH3:15][N:16]1[C:11](=[O:13])[C@H:10]([CH2:9][S:8][S:7][CH2:1][C@@H:2]2[C:3](=[O:5])[N:16]([CH3:15])[C:17](=[O:18])[NH:6]2)[NH:14][C:17]1=[O:18]

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 67678(-)-Cystine

生成物 1

HCID 88616268(R,S)-Bis-(1-methyl-2,5-dioxo-4-imidazolidinyl-methyl)-disulphide

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

To a mixture of L-cystine (12 g) and 2 molar sodium hydroxide solution (50 ml), cooled to 0°-5° C. in an ice bath, was added, dropwise, methyl isocyanate (8.55 g). The clear solution was stirred at 0° for 2 hours, and then at room temperature over night.

後処理

  1. temperaturecooled to 0°-5° C. in an ice bath
  2. additionwas added
  3. waitat room temperature over night

出典と根拠

ORDレコード
ord-a01e2a8168c54280999c179befc67799
出典データセット
uspto-grants-1990_11
特許番号
US04968711

関連ノート

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