Water → 2,2-Dichloro-3,3,3-trifluoro-1-(2,6-dichloro-4-nitrophenyl)-1-propanol

HRID 1073366ノート

反応式

HRID 1073366 の反応式
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[C:6]([Cl:13])[C:3]=1[CH:4]=[O:5].[C:14]([C:18]([Zn]Cl)([Cl:20])[Cl:19])([F:17])([F:16])[F:15].C(C(Cl)(Cl)Cl)(F)(F)F.O>CN(C=O)C.C1COCC1.[Zn]>[Cl:19][C:18]([Cl:20])([C:14]([F:17])([F:16])[F:15])[CH:4]([C:3]1[C:2]([Cl:1])=[CH:9][C:8]([N+:10]([O-:12])=[O:11])=[CH:7][C:6]=1[Cl:13])[OH:5]

参加物

8

反応物 4

HCID 962WaterHCID 96351,1,1-Trichloro-2,2,2-trifluoroethaneHCID 218388352,6-Dichloro-4-nitrobenzaldehydeHCID 178506323HCID 178506323、化合物

生成物 1

HCID 148485192,2-Dichloro-3,3,3-trifluoro-1-(2,6-dichloro-4-nitrophenyl)-1-propanol

試薬・触媒・溶媒 3

HCID 23994Zinc触媒HCID 6228Dimethylformamide溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

3 g of 2,6-dichloro-4-nitro benzaldehyde were reacted, in 20 ml of anhydrous DMF under a nitrogen atmosphere, with CF3CCl2ZnCl prepared from 5 g of CF3CCl3 and 2.2 g of Zn in 10 ml of THF at 60° C. for 1 hour. The mixture was heated at 50° C. for 2 hours and at the end of the reaction it was poured into acidulated water and extracted repeatedly with ethyl ether.

後処理

  1. additionwas poured
  2. extractionextracted repeatedly with ethyl ether

出典と根拠

ORDレコード
ord-74c3d48a7dcf426eb8066870b97680eb
出典データセット
uspto-grants-1990_11
特許番号
US04968847

反応ノート

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