Sodium Hydroxide → 1-(3-Amino-4',6'-dichlorophenyl)-pyrrolidin-2-one
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([NH:10][C:11](=[O:16])[CH2:12][CH2:13][CH2:14]Cl)[C:5]([Cl:9])=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[CH:3]=[C:4]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:16])[C:5]([Cl:9])=[CH:6][C:7]=1[Cl:8]参加物
4
実験手順
13.5 g (0.05 mol) of N-(3-amino-4,6-dichlorophenyl)-γ-chlorobutyramide, 200 ml of tetrahydrofurane and 100 ml of 1 N NaOH solution are stirred for 5 hours at 50° C. After the mixture has been allowed to cool, it is extracted three times with 300 ml of ethyl acetate and the extracts are washed with water, dried with magnesium sulphate and concentrated. The resulting product is recrystallised from toluene/ethyl acetate. Yield: 8.5 g; melting point 168°-170° C.
後処理
- temperatureto cool
- extractionit is extracted three times with 300 ml of ethyl acetate
- washthe extracts are washed with water
- dry with materialdried with magnesium sulphate
- concentrationconcentrated
- customThe resulting product is recrystallised from toluene/ethyl acetate
出典と根拠
- ORDレコード
- ord-4b0196f73fca4349a1b6f5d5bc29c5ca
- 出典データセット
- uspto-grants-1983_07
- 特許番号
- US04394156
反応ノート
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