Ethyl chloroacetate → HCID 178473171、化合物
反応式
[Na].[F:2][C:3]1[C:4](=[S:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.Cl[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>C(O)C>[CH2:16]([O:15][C:13]([CH2:12][S:10][C:4]1[C:3]([F:2])=[CH:8][NH:7][C:6](=[O:9])[N:5]=1)=[O:14])[CH3:17]参加物
5
実験手順
A solution of the sodium salt of 5-fluoro-4-thiouracil (0.0195 mol) and ethyl chloroacetate (0.0195 mol) in ethanol (50 ml) was heated under reflux for 2 hr. The solvent was removed at reduced pressure triturated with cold water and the residue recrystallised from water; yield 29%; m.p. 156° C. (Found: C, 41.38; H, 4.12. Calc for C8H9FN2O3S: C, 41.38; H, 3.90).
後処理
- temperatureunder reflux for 2 hr
- customThe solvent was removed at reduced pressure
- customtriturated with cold water
- customthe residue recrystallised from water
出典と根拠
- ORDレコード
- ord-26270973d6bf41888c6ce7ee99766551
- 出典データセット
- uspto-grants-1983_07
- 特許番号
- US04395406
反応ノート
読み込み中…