Toluene → 4p-Chlorophenyl-5-methyl-2-pyrrolidinone

HRID 1076232

反応式

HRID 1076232 の反応式
[N+:1]([CH2:4][CH3:5])([O-])=O.C(O[C:9](=[O:19])[CH:10]=[CH:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)C.[OH-].C[N+](C)(C)CC1C=CC=CC=1.C1(C)C=CC=CC=1>CO>[Cl:18][C:15]1[CH:14]=[CH:13][C:12]([CH:11]2[CH:4]([CH3:5])[NH:1][C:9](=[O:19])[CH2:10]2)=[CH:17][CH:16]=1

参加物

6

反応物 4

HCID 1140TolueneHCID 6587NitroethaneHCID 66854Benzyltrimethylammonium hydroxideHCID 2014712-Propenoic acid, 3-(4-chlorophenyl)-, ethyl ester

生成物 1

HCID 123953184p-Chlorophenyl-5-methyl-2-pyrrolidinone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 150 g. (2 mole) of nitroethane, 105 g. (0.5 mole) of ethyl-p-chlorocinnamate and 6.6 g. of Triton B (a 35% solution of trimethyl-benzyl-ammonium hydroxide in methanol) is heated for 20 hours at 80°C. After the reaction has finished, toluene is added, washing is carried out with a saturated solution of sodium chloride and the organic solution is dried and evaporated to dryness and the residue is distilled. Yield: 80%; B.P.: 150°-155°C./0.3 mm.Hg.

後処理

  1. additionA mixture of 150 g
  2. washwashing
  3. customthe organic solution is dried
  4. customevaporated to dryness
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-faaf505d44704321a69020ba2cb9a13a
出典データセット
uspto-grants-1976_05
特許番号
US03956314

関連ノート

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