Formaldehyde → HCID 21535614、化合物

HRID 1076997

反応式

HRID 1076997 の反応式
[C:1]([N:5]([CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:4])[CH2:2][CH3:3].[CH2:18]=O.[CH:20]1[CH:21]=[C:22]2[C:27]3=[C:28]([C:30]([NH:32][C:33](=[O:34])[C:26]3=[CH:25][CH:24]=[CH:23]2)=[O:31])[CH:29]=1>CN(C)C=O>[O:31]=[C:30]1[C:28]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][C:26]=3[C:33](=[O:34])[N:32]1[CH2:18][N:15]1[CH2:14][CH2:13][CH:12]([N:5]([C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:1](=[O:4])[CH2:2][CH3:3])[CH2:17][CH2:16]1)[CH:21]=[CH:20][CH:29]=2

参加物

5

反応物 3

HCID 712FormaldehydeHCID 66491NaphthalimideHCID 2593814-(N-Propionylaniline)piperidine

生成物 1

HCID 21535614HCID 21535614、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

An equimolar mixture of 4-(N-propionylanilino)piperidine, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield N-[1-[(1,3-dihydro-1,3-dioxo-2H-benz[de]isoquinolin-2-yl)methyl]-4-piperidinyl]-N-phenylpropanamide.

後処理

  1. temperaturethe mixture is heated until dissolution
  2. customto stand at room temperature
  3. filtrationthe resulting precipitate is filtered off
  4. customdried

出典と根拠

ORDレコード
ord-fd5645c8b7274977960199a92827b267
出典データセット
uspto-grants-1976_05
特許番号
US03959286

関連ノート

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