Trimethyl borate → 3-Fluoro-5-(4-fluorophenoxy)phenylboronic acid
反応式
[F:1][C:2]1[CH:3]=[C:4](Br)[CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:7]=1.C([Li])CCC.[B:22](OC)([O:25]C)[O:23]C>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([B:22]([OH:25])[OH:23])[CH:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:7]=1参加物
5
実験手順
This compound is prepared in a manner analogous to that of Step B of Example 6, using 9.1 grams (0.032 mole) of 3-fluoro-5-(4-fluorophenoxy)phenyl bromide, 14 mL (0.035 mole) of n-butyllithium (2.5M in hexanes), and 10.4 mL (0.095 mole) of trimethyl borate in 100 mL of tetrahydrofuran, yielding 3-fluoro-5-(4-fluorophenoxy)phenylboronic acid.
後処理
- customThis compound is prepared in a manner analogous to that of Step B of Example 6
出典と根拠
- ORDレコード
- ord-ea1b1ffeaa6b4e93a6f18d94fbf9366a
- 出典データセット
- uspto-grants-1996_08
- 特許番号
- US05547954
反応ノート
読み込み中…